Acute Febrile Neutrophilic Dermatosis

Acute Febrile Neutrophilic Dermatosis

Acute febrile neutrophilic dermatosis, also known as Sweet’s syndrome, is a condition typified by the sudden, simultaneous onset of fever; increased white blood cell count; and tender, red-to-purple lesions.

Causes

The risk of acute febrile neutrophilic dermatosis is increased considerably for patients with certain pre-existing disorders, including:

·         Acute respiratory disorder;

·         Infection of the gastro-intestinal tract;

·         Autoimmune disorders; or

·         Cancer.

Pathophysiology

Acute febrile neutrophilic dermatosis occurs as a reaction to systemic factors, such as infection, inflammation or exposure to particular substances.

Symptoms and diagnosis

Aside from the characteristic signs, other symptoms associated with acute febrile neutrophilic dermatosis include:

·         Inflammation membranes surrounding the eye;

·         Joint pain; and

·         Dysfunction of internal organs.

Patients with the condition are usually diagnosed based on inspection of the hallmark lesions. Clinical analysis of a sample of lesioned skin can be used to confirm the diagnosis.

Treatment

Drugs can be used effectively to restore bodily temperature, white blood cell count and the condition of the skin to normal.

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