Gastrointestinal Stromal Tumors

Also Know As GIST

Sign/Symptoms
Abdominal Bleeding Abdominal Bloating Abdominal Swelling Anaemia (Anemia) Appetite Loss (Anorexia) Fatigue Pain Abdominal Weight Loss (Body Mass Index Decreased)

Drugs
Imatinib

Treatments
Surgery Resection Medical Procedure Radiation Treatment Chemotherapy Medical Therapy Chemotherapy Weakly in Favour Low Evidence Radiation Treatment Weakly in Favour Low Evidence Resection Weakly in Favour Low Evidence

Attributes
Commonality is common commonality is rare Incidence is approximately 1 in 833,333 people

Further Tests
Alpha-1 Antitrypsin (AAT) Concentration Alpha-1 Antintrypsin (AAT) (Increased) Cerebrospinal Fluid Albumin Concentration Albumin (Cerebrospinal Fluid, CSF) (Increased) Cerebrospinal Fluid Protein Concentration Cerebrospinal Fluid Total Protein (Increased) Cerebrospinal Fluid Protein Electrophoresis Albumin (Cerebrospinal Fluid, CSF) (Increased) Cerebrospinal Fluid White Cell Differential Cerebrospinal Fluid Neutrophil Differential (Increased) Fecal Occult Blood Test Fecal Blood (Increased) Fibrin Monomers Test Fibrin Monomers (Increased) Plasminogen Activity Plasminogen (Decreased) Platelet Count Platelets (Increased) Thyroxine (Total T4) Concentration Thyroxine (Total T4) (Decreased) Thyroxine (Total T4) (Decreased) Triiodothyronine (Total T3) Concentration Triiodothyronine (Total T3) (Decreased) Triiodothyronine (Total T3) (Decreased)

Gastrointestinal stromal tumor

Gastrointestinal stromal tumor is the term used for tumors located in the gastrointestinal tract. These tumors manifest from the mutation of a gene called CKIT. Some cases of gastrointestinal stromal tumor are a side effect of abdominal radiation therapy. Most gastrointestinal stromal tumors develop in the stomach and usually affect people over the age of 50. Symptoms may vary depending on the location and the level of development of the tumor. Symptoms include bleeding and dyspepsia. Endoscopy is done to diagnose the presence of gastrointestinal stromal tumor. Surgery is required to remove the tumors.

Summary References

Treatments:

1. http://www.surgjournal.com/article/S0039-6060%2803%2900314-3/abstract

2. Nguyen SQ, Divino CM, Wang JL, Dikman SH (May 2006). "Laparoscopic management of gastrointestinal stromal tumors". Surg Endosc 20 (5): 713–6. doi:10.1007/s00464-005-0435-

3. "News: Genetic Variations in GI Tumors Determine Which Medications Are Efficacious.". Genetic Engineering & Biotechnology News. 13 Nov 2008. http://www.genengnews.com/news/bnitem.aspx?name=45436906&source=genwire.

4. http://www.merck.com/mmpe/sec02/ch021/ch021e.html?qt=Gastrointestinal%20Stromal%20Tumors&alt=sh

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