Hypertrophic Cardiomyopathy

Also Know As Asymmetic Septal Hypertrophy (ASH)

Sign/Symptoms
Blood Pressure High (Hypertension) Breath Shortness (Dyspnoea) Fainting (Syncope) Fatigue Heart Failure Heart Murmur (Detected by Stethoscope) Heart Rate Irregular (Arrhythmia) Heartbeats Felt By Patient (Palpitations) Lung Fluid Accumulation (Oedema Pulmonary) Mind: Lightheadedness Pain: Chest

Drugs
Timolol

Treatments
Surgery Cardiac Defibrillator Implant Heart Transplant Myomectomy Septal Myotomy Medical Procedure Alcohol Septal Ablation Medical Therapy Alcohol Septal Ablation Weakly in Favour Low Evidence Cardiac Defibrillator Implant Weakly in Favour Low Evidence Heart Transplant Weakly in Favour Low Evidence Myomectomy Weakly in Favour Low Evidence Septal Myotomy Weakly in Favour Low Evidence

Attributes
Incidence is approximately 1 in 5,000 people

Further Tests
2,3 Diphosphoglycerate (2,3-DPG) Concentration 2,3 Diphosphoglycerate (2,3-DPG) (Increased) Fibrinogen Concentration test Fibrinogen (Increased) Heamatocrit (Hct) RBC Mass (Increased) Hemoglobin (Hb) Concentration Hemoglobin (Hb) (Increased) Homocysteine Concentration (HCY, Blood) Homocysteine (Increased) Red Blood Cell (RBC) Count Red Blood Cells (RBC) (Increased)

Summary References

Treatments:

1. http://www.merck.com/mmpe/sec07/ch084666/ch084666c.html?qt=hypertrophic%20cardiomyopathy&alt=sh#S08_CH84666_CH84666c-27

2. Maron BJ (Mar 2002). "Hypertrophic cardiomyopathy: a systematic review". JAMA 287 (10): 1308–20. doi:10.1001/jama.287.10.1308

3. Sherrid MV, Chaudhry FA, Swistel DG (Feb 2003). "Obstructive hypertrophic cardiomyopathy: echocardiography, pathophysiology, and the continuing evolution of surgery for obstruction". Ann Thorac Surg. 75 (2): 620–32. doi:10.1016/S0003-4975(02)04546-0

4. Wigle ED, Rakowski H, Kimball BP, Williams WG (Oct 1995). "Hypertrophic cardiomyopathy. Clinical spectrum and treatment". Circulation 92 (7): 1680–92.

5. Maron BJ, McKenna WJ, Danielson GK, et al. (Nov 2003). "American College of Cardiology/European Society of Cardiology clinical expert consensus document on hypertrophic cardiomyopathy. A report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents and the European Society of Cardiology Committee for Practice Guidelines". J Am Coll Cardiol 42 (9): 1687–713.

6. Sherrid MV, Barac I, McKenna WJ, et al. (Apr 2005). "Multicenter study of the efficacy and safety of disopyramide in obstructive hypertrophic cardiomyopathy". J Am Coll Cardiol. 45 (8): 1251–8. doi:10.1016/j.jacc.2005.01.012

7. Morrow AG (Oct 1978). "Hypertrophic subaortic stenosis. Operative methods utilized to relieve left ventricular outflow obstruction". J Thorac Cardiovasc Surg. 76 (4): 423–30

8. Brilakis ES, Nishimura RA (Jul 2003). "Severe pulmonary hypertension in a patient with hypertrophic cardiomyopathy: response to alcohol septal ablation". Heart 89 (7): 790. doi:10.1136/heart.89.7.790. PMID 12807862

9. Ommen SR, Nishimura RA, Squires RW, Schaff HV, Danielson GK, Tajik AJ (Jul 1999). "Comparison of dual-chamber pacing versus septal myectomy for the treatment of patients with hypertrophic obstructive cardiomyopathy: a comparison of objective hemodynamic and exercise end points". J Am Coll Cardiol 34 (1): 191–6. doi:10.1016/S0735-1097(99)00173-4

10. http://www.ncbi.nlm.nih.gov/pubmed/9763923

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