Dolasetron

5HT3 Antogonists
Identification
Generic Name
Dolasetron
Brand Name

 
Attributes
Pregnancy
B1
Indication
Nausea
Vomiting
Condition Contra-Indication
Our Records are Incomplete for Condition-Contra Indications

 
Other Contra-Indication
This drug is contra-indicated in patients with a history of allergies to it

Contra-Indication
Our Records are Incomplete for Drug Contra-Indications

 
Class Contra-Indication
Our Records are Incomplete for Drug Class Contra-Indications
Side Effects
Common
Constipation
Headache (Cephalgia)
Blood Transaminase Raised in Liver
Diarrhoea (Diarrhea)
Dizziness
Sense of Taste Abnormal
Uncommon
Stomach Or Intestinal Upset (Dyspepsia)
Pain Abdominal
Fatigue
Heart or Pulse Rate Raised (Tachycardia)
Indigestion (Dyspepsia)
Rare
Heart Rate Irregular (Arrhythmia)
Anaphylactic Shock
ECG Changes
Blood Pressure Below Normal (Hypotension)
Heart Rate Decrease Or Abnormally Low (Bradycardia)
Seizures
Pancreatitis (Inflammation Of The Pancreas)
Skin Yellowing (Jaundice)
Blood Flow Reduced (Ischaemia)

Dolasetron

 

 

Dolasetron (trade name Anzemet) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy. Its main effect is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata. It does not have much antiemetic effect when symptoms are due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptors.

Dolasetron breaks down slowly, staying in the body for a long time. One dose usually lasts 4 to 9 hours and is usually administered once or twice daily. This drug is removed from the body by the liver and kidneys.

Clinical uses

  • Chemotherapy-induced nausea and vomiting
    • 5-HT3 receptor antagonists are the primary drugs used to treat and prevent chemotherapy-induced nausea and vomiting. Many times they are given intravenously about 30 minutes before beginning therapy.
  • Post-operative and post-radiation nausea and vomiting
  • Is a possible therapy for nausea and vomiting due to acute or chronic medical illness or acute gastroenteritis
  • Unlike most other 5HT3 antagonists, data is lacking for use of dolasetron with aprepitant in chemotherapy-induced nausea and vomiting (CINV).

Adverse effects

Dolasetron is a well-tolerated drug with few side effects. Headache, dizziness, and constipations are the most commonly reported side effects associated with its use. There have been no significant drug interactions reported with this drug's use. It is broken down by the liver's cytochrome P450 system and it has little effect on the metabolism of other drugs broken down by this system.

See also

References

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