| Identification |
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Generic Name
Dorzolamide
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Brand Name
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| Condition Contra-Indication |
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Asthma
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Hemorrhage Shock
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| Other Contra-Indication |
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This drug is contra-indicated in patients with chronic obstructive pulmonary disease, sinus bradycardia, 2nd or 3rd degree heart block, cardiac failure, or a history of allergies to the drug
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| Contra-Indication |
Our Records are Incomplete for Drug Contra-Indications |
| Class Contra-Indication |
Our Records are Incomplete for Drug Class Contra-Indications |
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| Side Effects |
| Common Eye: Inflammation of Conjunctiva (Conjunctivitis) | | Uncommon Vision Blurred Headache (Cephalgia) Dizziness Skin Tingling Or Numbness (Paresthesias) Dermatitis Angina Fainting (Syncope) | | Rare Mind: Hallucination Mind: Agitation Mind: Depression Appetite Loss (Anorexia) Mind: Dementia Skin Itchy Swollen Red Bumps (Hives or Urticaria) Skin: Swelling Beneath The Skin (Angioedema) Lungs: Airways obstruction (Bronchospasm) |
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Dorzolamide
Dorzolamide (trade name Trusopt) is a carbonic anhydrase inhibitor. It is an anti-glaucoma agent and topically applied in the form of eye drops. This drug, developed by Merck, was the first drug in human therapy (market introduction 1995) which resulted from structure-based drug design. Dorzolamide hydrochloride is used to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension.
The combination of dorzolamide with timolol is marketed under the trade name Cosopt
Further reading
- Kubinyi H (1999). "Chance favors the prepared mind--from serendipity to rational drug design". J Recept Signal Transduct Res 19 (1-4): 15–39. doi:10.3109/10799899909036635. PMID 10071748.
- Plummer C, MacKay E, Gelatt K (2006). "Comparison of the effects of topical administration of a fixed combination of dorzolamide-timolol to monotherapy with timolol or dorzolamide on IOP, pupil size, and heart rate in glaucomatous dogs.". Vet Ophthalmol 9 (4): 245–9. doi:10.1111/j.1463-5224.2006.00469.x. PMID 16771760.
- Grover S, Apushkin M, Fishman G (2006). "Topical dorzolamide for the treatment of cystoid macular edema in patients with retinitis pigmentosa.". Am J Ophthalmol 141 (5): 850–8. doi:10.1016/j.ajo.2005.12.030. PMID 16546110.
- Almeida G, Faria e Souza S (2006). "Effect of topical dorzolamide on rabbit central corneal thickness.". Braz J Med Biol Res 39 (2): 277–81. doi:10.1590/S0100-879X2006000200015. PMID 16470316.
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