Methyltetrahydrofolate (5 MTHF)

 

Other Contra-Indication

Our Records are Incomplete for Other Contra-Indications

 

Class Contra-Indication

Our Records are Incomplete for Drug Class Contra-Indications

Folic acid is well-tolerated in supplements in doses less than 1 mg per day, the rare side effects are generally a result of doses of more than 5 mg per day . Folic acid doses of more than 15 mg per day can cause seizures and psychotic behavior.

Efficacy of Methyltetrahydrofolate as an Alternative Medicine According to GRADE* Ranking: 


Alzheimer's Disease [1, 2, 3, 4, 5, 6]:

Recommendation: Weakly in favor (5 MTHF has been found to reduce the homocysteine ( tHcy) levels, high tHcy levels are a significant risk factor for AD. More studies are needed)

Grade of Evidence: Low level of evidence

* www.gradeworkinggroup.org 

References:

1.  http://ajcn.nutrition.org/content/79/3/473.full

2. http://www.ncbi.nlm.nih.gov/pubmed/3735413

3. http://www.ncbi.nlm.nih.gov/pubmed/19661622

4. http://www.ncbi.nlm.nih.gov/pubmed/23099812

5. http://articles.mercola.com/sites/articles/archive/2013/06/03/vitamin-b.aspx

6. http://primarypsychiatry.com/l-methylfolate-methylcobalamin-and-n-acetylcysteine-in-the-treatment-of-alzheimeras-diseasearelated-cognitive-decline/

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