Hereditary Vitamin D Dependent Rickets

Efficacy of Alternative and Other Treatments According to GRADE* Ranking:

Vitamin D [1, 2, 3, 4, 5, 6, 7, 8, 9, 10]:

Please note, this management does NOT treat the condition itself. It may mildly help in preventing some of the symptoms, and even then has insufficient evidence to back up this claim at present. Please note, this acts as a PREVENTATIVE treatment, and not necessarily symptomatic relief.

Recommendation: strongly in favor (Studies have shown that a Vitamin D can help to prevent and treat rickets)

Grade of Evidence: high quality of evidence

Calcium Supplement [11, 12, 13, 14]:

Please note, this management does NOT treat the condition itself. It may mildly help in preventing some of the symptoms, and even then has insufficient evidence to back up this claim at present. Please note, this acts as a PREVENTATIVE treatment, and not necessarily symptomatic relief.

Recommendation: strongly in favor (Studies show that calcium supplements may be beneficial to those with rickets)

Grade of Evidence: high quality of evidence

Phosphate Supplements [15, 16]:

Please note, this management does NOT treat the condition itself. It may mildly help in preventing some of the symptoms, and even then has insufficient evidence to back up this claim at present. Please note, this acts as a PREVENTATIVE treatment, and not necessarily symptomatic relief.

Recommendation: weakly in favor (Early studies show that phosphate supplements may be able to help those with rickets. Further studies are needed)

Grade of Evidence: low quality of evidence

* www.gradeworkinggroup.org

 

Summary References

Treatments:

1. http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/vitamin-d

2. http://onlinelibrary.wiley.com/o/cochrane/clsysrev/articles/CD006164/frame.html

3. http://www.ncbi.nlm.nih.gov/pubmed/10824056

4. http://onlinelibrary.wiley.com/doi/10.1002/jcb.10338/abstract

5. http://pain-topics.org/pdf/vitamind-report.pdf

6. http://informahealthcare.com/doi/abs/10.1185/030079908X253519

7. http://www.theglobeandmail.com/life/article756975.ece

8. http://www.ncbi.nlm.nih.gov/pubmed/17556697

9. http://www.ncbi.nlm.nih.gov/pubmed/18065602

10. http://www.nlm.nih.gov/medlineplus/vitamind.html
 

11. http://ajcn.nutrition.org/content/80/6/1725S.full

12. http://www.ncbi.nlm.nih.gov/pubmed/15585795

13. http://www.nature.com/bonekeyreports/2014/140319/bonekey201419/full/bonekey201419.html

14. https://clinicaltrials.gov/ct2/show/NCT01578434

15. http://www.endocrineconnections.com/content/3/1/R13.full

16. http://www.ncbi.nlm.nih.gov/pubmed/6259210

Public Discussion