Esophageal Cancer

Sign/Symptoms
Cough Coughing Up Blood (Haemoptysis, Hemoptysis) Fever (Raised Body Temperature) Hiccups Nausea Pain: Chest Regurgitation of Food Swallowing Difficulty (Dysphagia) Swallowing Is Painful (Odynophogia) Vomiting Weight Loss (Body Mass Index Decreased)

Drugs
Fentanyl

Treatments
Surgery Lymph Node Resection Resection Stenting Transthoracic Esophagectomy Medical Procedure Radiation Treatment Photodynamic therapy Weakly in Favour Moderate Evidence Laser Treatment Intubation Continuous Positive Airway Pressure Chemotherapy Brachytherapy Endoscopic Procedures Endoscopic Mucosal Resection Vitamins Selenium Supplementation Weakly in Favour Very Low Evidence Minerals Selenium Supplementation Weakly in Favour Very Low Evidence Alternative Medicine Green Tea Weakly in Favour Low Evidence Tumeric (Curcuma longa) Weakly in Favour Low Evidence Rabdosia Rubescens (Dong Ling Cao, Oridonin, Isodon Rubescens) Strongly in Favour Moderate Evidence Medical Therapy Endoscopic Mucosal Resection Weakly in Favour Low Evidence Brachytherapy Weakly in Favour Low Evidence Chemotherapy Weakly in Favour Low Evidence Intubation Weakly in Favour Low Evidence Laser Treatment Weakly in Favour Low Evidence Photodynamic therapy Weakly in Favour Low Evidence Radiation Treatment Weakly in Favour Low Evidence Lymph Node Resection Weakly in Favour Low Evidence Resection Weakly in Favour Low Evidence Stenting Weakly in Favour Low Evidence Transthoracic Esophagectomy Weakly in Favour Low Evidence

Attributes

Our Records are Incomplete for Condition Attributes

Further Tests
Alpha-1 Antitrypsin (AAT) Concentration Alpha-1 Antintrypsin (AAT) (Increased) Antithrombin 111 (AT-111) Activity Test Antithrombin 111 (AT-111) (Decreased) Blood Uric Acid Concentration Test Uric Acid, Blood (Increased) Cerebrospinal Fluid Glucose Concentration Glucose (Cerebrospinal Fluid) (Decreased) Cerebrospinal Fluid Protein Concentration Cerebrospinal Fluid Total Protein (Increased) Cerebrospinal Fluid White Cell Differential Cerebrospinal Fluid Leukocytes (Increased) Cerebrospinal Fluid Neutrophil Differential (Increased) D-Dimer Blood Test D-Dimer (Increased) Eosinophils Count Eosinophils (Increased) Fecal Occult Blood Test Fecal Blood (Increased) Fibrin Degradation Products (FDPs, Fibrin Split Products, FSPs, Fibrin Breakdown Products, Fbps) Fibrin Split Products (Increased) Fibrin Monomers Test Fibrin Monomers (Increased) Fibrinopeptide A (FPA) Action Assay Fibrinopeptide A (FPA) (Increased) Folic Acid (Folate) Concentration Folic Acid (Folate) (Decreased) Functional Residual Capacity Functional Residual Capacity (Decreased) haptoglobin (Hp) concentration haptoglobin (Hp) (Increased) Iron Concentration Iron (Decreased) Low Density Lipoprotein (LDL) Concentration Low Density Lipoprotein (LDL) (Decreased) Neutrophil Absolute Count Segmented Neutrophils (Increased) Platelet Count Platelets (Increased) Potassium Concentration (K, Blood) Potassium (K, Blood) (Decreased) Protein Electrophoresis (Blood, Serum Protein) Gamma Globulin (Blood, Serum) (Increased) Thyroid Stimulating Horomone (TSH) Concentration Thyroid Stimulating Horomone (TSH) (Increased) Thyroxine (Total T4) Concentration Thyroxine (Total T4) (Decreased) Thyroxine (Total T4) (Decreased) Triiodothyronine (Free T3) Concentration Triiodothyronine (Free T3) (Decreased) Triiodothyronine (Total T3) Concentration Triiodothyronine (Total T3) (Decreased) Triiodothyronine (Total T3) (Decreased) Triiodothyronine Uptake Test Triiodothyronine Uptake Percentage (Increased) Vitamin B12 (VB12) Concentration Vitamin B12 (VB12) (Decreased) White Blood Cell (WBC) Count White Blood Cell (WBC) (Increased)

Efficacy of Alternative and Other Treatments According to GRADE* Ranking:

Turmeric [1, 23, 24, 25, 26, 27, 28]:

Please note, this management does NOT treat the condition itself. It is proposed only as a weak supportive symptomatic support, and even then, has insufficient evidence to back up this claim at present.

Recommendation: Weakly in favor (Early laboratory studies show that turmeric may be of benefit in the treatment of cancer. However, clinical trials on humans are needed)

Grade of Evidence: low quality of evidence

Selenium Supplement [1, 14, 15, 16, 17, 18, 19. 20, 21, 22]:

Please note, this management does NOT treat the condition itself. It may mildly help with some of the symptoms, and even then has insufficient evidence to back up this claim at present. IMPORTANT: Selenium is toxic in high doses. Massive overdoses can cause kidney failure, breathing difficulty and death. Selenium should only be taken at healthy levels which the body is able to tolerate.

Recommendation: Weakly in favor (Observational studies have shown that taking adequate daily amounts of selenium can help prevent esophageal cancer. However, these are very unreliable studies, and more research is needed.)

Grade of Evidence: very low quality of evidence

Rabdosia Rubescens (Dong Ling Cao, Oridonin, Isodon Rubescens) [2, 8, 9, 10, 11, 12, 13]:

Please note, this management does NOT treat the condition itself. It may mildly help with some of the symptoms, and even then has insufficient evidence to back up this claim at present.

Recommendation: Strongly in favor (Clinical trials have shown that Rabdosia Rubescens increases suvival when used in combination with chemotherapy to treat esophageal cancer)

Grade of Evidence: moderate quality of evidence

Green Tea [2, 3, 4, 5, 6, 7]:

Please note, this management does NOT treat the condition itself. It may mildly help with some of the symptoms, and even then has insufficient evidence to back up this claim at present.

Recommendation: Weakly in favor (Laboratory studies have shown promise with regards to the prevention of esophageal cancer with green tea, but very few reliable clinical trials have been done. More research is needed.)

Grade of Evidence: low quality of evidence

Photodynamic Therapy:

Recommendation: weakly in favor (Photodynamic therapy is effective as a potential treatment for esophageal cancer)

Grade of Evidence: moderate quality of evidence

* www.gradeworkinggroup.org

Summary References

Treatments:

1. http://www.merck.com/mmpe/sec02/ch021/ch021c.html?qt=cancer&alt=sh#sec02-ch021-ch021a-1409a

2. Ades T, Alteri R, Gansler T, Yeargin P, "Complete Guide to Complimentary & Alternative Cancer Therapies", American Cancer Society, Atlanta USA, 2009

3. http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/green-tea

4. http://www.ncbi.nlm.nih.gov/pubmed/16968850

5. http://www.denverpost.com/nationworld/ci_4326770

6. http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-green_tea.html

7. http://nccam.nih.gov/health/greentea/index.htm

8. http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?fs=ND&pt=100&id=1140&AspxAutoDetectCookieSupport=1

9. http://mct.aacrjournals.org/content/4/4/578.abstract

10. http://www.ncbi.nlm.nih.gov/pubmed/15586232

11. http://www.webmd.com/vitamins-supplements/ingredientmono-1140-RABDOSIA RUBESCENS.aspx?activeIngredientId=1140&activeIngredientName=RABDOSIA RUBESCENS

12. http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/rabdosia-rubescens

13. http://alternativehealing.org/dong_ling_cao.htm

14. http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/selenium?sitearea=ETO

15. http://www.cancer.gov/Templates/doc.aspx?viewid=ED8AD8E8-6AE5-458D-8091-393F4CB73F0D

16. http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-selenium.html

17. http://www.ncbi.nlm.nih.gov/pubmed/9290116

18. http://www.ncbi.nlm.nih.gov/pubmed/9829869

19. http://www.ncbi.nlm.nih.gov/pubmed/10335455

20. http://www.ncbi.nlm.nih.gov/pubmed/2136228

21. http://www.springerlink.com/content/v0r644v4ju5153k2/

22. http://jnci.oxfordjournals.org/cgi/content/full/101/5/283

23. http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/turmeric

24. http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-turmeric.html

25. http://nccam.nih.gov/health/turmeric/index.htm

26. http://news.bbc.co.uk/2/hi/health/1668932.stm

27. http://www.mirror.co.uk/news/top-stories/2009/10/28/curry-kills-cancer-cells-and-other-health-benefits-of-the-nations-favourite-dish-115875-21779950/

28. http://clinicaltrials.gov/ct2/results?term=turmeric

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