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Selenium Supplementation

Identification
Generic Name Selenium Supplementation
Brand Name

Indication
Acute Viral Hepatitis No Recommendation Very Low Evidence Chronic Hepatitis No Recommendation Very Low Evidence Euthyroid Goiter No Recommendation Very Low Evidence Hashimotos Thyroiditis No Recommendation Very Low Evidence Hyperthyroidism No Recommendation Very Low Evidence Hypothyroidism No Recommendation Very Low Evidence Ovarian Cancer Weakly in Favour Very Low Evidence Subclinical Hyperthyroidism No Recommendation Very Low Evidence Subclinical Hypothyroidism No Recommendation Very Low Evidence Thyroiditis No Recommendation Very Low Evidence Acute Coronary Syndromes No Recommendation Very Low Evidence Acute Pancreatitis No Recommendation Very Low Evidence Alzheimers Disease Weakly in Favour Very Low Evidence Asthma No Recommendation Very Low Evidence Bladder Cancer Weakly in Favour Very Low Evidence Breast Cancer Weakly in Favour Very Low Evidence Cervical Cancer Weakly in Favour Very Low Evidence Chronic Pancreatitis No Recommendation Very Low Evidence Esophageal Cancer Weakly in Favour Very Low Evidence Hypercholesterolaemia No Recommendation Very Low Evidence Occupational Asthma No Recommendation Very Low Evidence Pancreatic Cancer Weakly in Favour Very Low Evidence Pancreatitis No Recommendation Very Low Evidence Prostate Cancer No Recommendation Very Low Evidence Colon Cancer Weakly in Favour Very Low Evidence Colorectal Cancer Weakly in Favour Moderate Evidence Lung Cancer Weakly in Favour Very Low Evidence Coronary Heart Disease No Recommendation Very Low Evidence Hepatitis A No Recommendation Very Low Evidence Hepatitis B Infection No Recommendation Very Low Evidence Hepatitis C Infection No Recommendation Very Low Evidence Hepatitis E Infection No Recommendation Very Low Evidence Hepatitis D Infection No Recommendation Very Low Evidence Ischaemic Heart Disease No Recommendation Very Low Evidence Hyperlipidemia No Recommendation Very Low Evidence Familial Hypercholesterolemia No Recommendation Very Low Evidence

Condition Contra-Indication
Our Records are Incomplete for Condition-Contra Indications

Other Contra-Indication

Our Records are Incomplete for Other Contra-Indications

Contra-Indication
Our Records are Incomplete for Drug Contra-Indications

Class Contra-Indication

Our Records are Incomplete for Drug Class Contra-Indications

We have incomplete side-effect data.

Side Effects

Efficacy of Selenium Supplementation as an Alternative Medicine According to GRADE*

Recommendation: No recommendation (There is insufficient evidence to support claims that selenium supplementation helps to treat hepatitis, goiter, thyroiditis, hyperthyroidism, hypothyroidism, acute coronary syndromes, pancreatitis, asthma, hypercholesterolaemia, prostate cancer, heart disease, hyperlipidemia. More research is needed.)

Grade of Evidence: Very low level of evidence

Ovarian Cancer [1, 2, 3, 4, 5, 6, 7, 8, 9]:

Recommendation: Weakly in favor (Observational studies have shown that taking adequate daily amounts of selenium can help prevent ovarian cancer. However, these are very unreliable studies, and more research is needed.)

Grade of Evidence: Very low level of evidence

Alzheimer's Disease [10, 11, 12]:

Recommendation: Weakly in Favor (Current evidence does not indicate it is an effective treatment for AD but some evidence shows selenium to be an effective preventive strategy for the development of AD, however it is likely to be useful in conjunction with other treatments)

Grade of Evidence: Very low level of evidence

Bladder Cancer [1, 2, 3, 4, 5, 6, 7, 8, 9]:

Recommendation: Weakly in favor (Observational studies have shown that taking adequate daily amounts of selenium can help prevent bladder cancer. However, these are very unreliable studies, and more research is needed.)

Grade of Evidence: Very low level of evidence

Breast Cancer [1, 2, 3, 4, 5, 6, 7, 8, 9]:

Recommendation: Weakly in favor (Observational studies have shown that taking adequate daily amounts of selenium can help prevent breast cancer. However, these are very unreliable studies, and more research is needed.)

Grade of Evidence: Very low level of evidence

Esophageal Cancer [1, 2, 3, 4, 5, 6, 7, 8, 9]:

Recommendation: Weakly in favor (Observational studies have shown that taking adequate daily amounts of selenium can help prevent esophageal cancer. However, these are very unreliable studies, and more research is needed.)

Grade of Evidence: Very low level of evidence

Pancreatic Cancer [1, 2, 3, 4, 5, 6, 7, 8, 9]:

Recommendation: Weakly in favor (Observational studies have shown that taking adequate daily amounts of selenium can help prevent pancreatic cancer. However, these are very unreliable studies, and more research is needed.)

Grade of Evidence: Very low level of evidence

Colon Cancer [1, 2, 3, 4, 5, 6, 7, 8, 9]:

Recommendation: Weakly in favor (Observational studies have shown that taking adequate daily amounts of selenium can help prevent colon cancer. However, these are very unreliable studies, and more research is needed.)

Grade of Evidence: Very low level of evidence

Colorectal Cancer [1, 2, 3, 4, 5, 6, 7, 8, 9]:

Recommendation: Weakly in favor (Observational studies have shown that taking adequate daily amounts of selenium can help prevent colorectal cancer. However, these are very unreliable studies, and more research is needed.)

Grade of Evidence: Very low level of evidence

Lung Cancer [1, 2, 3, 4, 5, 6, 7, 8, 9]:

Recommendation: Weakly in favor (Observational studies have shown that taking adequate daily amounts of selenium can help prevent lung cancer. However, these are very unreliable studies, and more research is needed.)

Grade of Evidence: Very low level of evidence

* www.gradeworkinggroup.org

References:

1. Ades T, Alteri R, Gansler T, Yeargin P, "Complete Guide to Complimentary & Alternative Cancer Therapies", American Cancer Society, Atlanta USA, 2009

2. http://www.cancer.gov/Templates/doc.aspx?viewid=ED8AD8E8-6AE5-458D-8091-393F4CB73F0D

3. http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-selenium.html

4. http://www.ncbi.nlm.nih.gov/pubmed/9290116

5. http://www.ncbi.nlm.nih.gov/pubmed/9829869

6. http://www.ncbi.nlm.nih.gov/pubmed/10335455

7. http://www.ncbi.nlm.nih.gov/pubmed/2136228

8. http://www.springerlink.com/content/v0r644v4ju5153k2/

9. http://jnci.oxfordjournals.org/cgi/content/full/101/5/283

10. http://www.ncbi.nlm.nih.gov/pubmed/22536767

11. http://www.ncbi.nlm.nih.gov/pubmed/17272290

12. http://www.ncbi.nlm.nih.gov/pubmed/15207438

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