Subclinical Hypothyroidism

Sign/Symptoms
Appetite Or Hunger Increase Constipation Fatigue Pain Bone Skin: Pale, Lack of Colour (Pallid Complexion) Weight Gain (Body Mass Index Raised)

Drugs
Thyroxine

Treatments
Vitamins Selenium Supplementation No Recommendation Very Low Evidence Minerals Selenium Supplementation No Recommendation Very Low Evidence Alternative Medicine Saw Palmetto Extract No Recommendation Very Low Evidence St Johns Wort (Goatweed, Tipton Weed, Hypericum Perforatum) No Recommendation Low Evidence

Attributes

Our Records are Incomplete for Condition Attributes

Further Tests
Bilirubin Concentration (Neonates, Neonatal Bilirubin) Bilirubin (Unconjugated Fraction) (Increased) Glucose Tolerance Test (GTT, OGTT, 120 Minutes After Glucose Load) Glucose (Blood) (Decreased) Glucose Tolerance Test (GTT, OGTT, 160 Minutes After Glucose Load) Glucose (Blood) (Decreased) Glucose Tolerance Test (GTT, OGTT, 30 Minutes After Glucose Load) Glucose (Blood) (Decreased) Glucose Tolerance Test (GTT, OGTT, 60 Minutes After Glucose Load) Glucose (Blood) (Decreased) Glucose Tolerance Test (GTT, OGTT, Fasting Glucose) Glucose (Blood) (Decreased) Glucose Tolerance Test for Gestational Diabetes (1 Hour After Glucose Load) Glucose (Blood) (Decreased) Glucose Tolerance Test for Gestational Diabetes (Fasting Glucose Value) Glucose (Blood) (Decreased) Glucose, Blood (Fasting Blood Glucose) Glucose (Blood) (Decreased) Glucose, Blood (Post Prandiol Blood Glucose Test, 2 Hour Post Meal Blood Glucose) Glucose (Blood) (Decreased) Glucose, Blood (Random Blood Glucose Test) Glucose (Blood) (Decreased) Magnesium Concentration (Mg, Blood) Magnesium (Mg, Blood) (Increased) Sodium Concentration (Na, Blood) Sodium (Na, Blood) (Decreased) Sweat Testing Sodium (Na, Sweat) (Increased) Chloride (Sweat, Cl) (Increased) Thyroid Stimulating Horomone (TSH) Concentration Thyroid Stimulating Horomone (TSH) (Decreased) Thyroxine (Free T4) Concentration Thyroxine Index (Free T4) (Decreased) Thyroxine (Total T4) Concentration Thyroxine (Total T4) (Decreased) Thyroxine (Total T4) (Decreased) Thyroxine Binding Globulin Concentration (TBG, Thyroid Binding Globulin, Blood) Thyroxine Binding Globulin (TBG, Thyroid Binding Globulin, Blood) (Increased) Triiodothyronine (Free T3) Concentration Triiodothyronine (Free T3) (Decreased) Triiodothyronine (Total T3) Concentration Triiodothyronine (Total T3) (Decreased) Triiodothyronine (Total T3) (Decreased) Triiodothyronine Uptake Test Triiodothyronine Uptake Percentage (Decreased) Urine Hydroxyproline Concentration Hydroxyproline (Urine Excretion Rate) (Decreased)

Efficacy of Alternative and Other Treatments According to GRADE* Ranking:

St John's Wort (Goatweed, tipton weed, Hypericum Perforatum) [1, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28]:

Please note, this management does NOT treat the condition itself. It may mildly help with some of the symptoms, and even then has insufficient evidence to back up this claim at present.

Recommendation: No recommendation (Available evidence does not support claims that St Johns Wort can help to treat hypothyroidism)

Grade of Evidence: low quality of evidence

Selenium Supplement [1, 9, 10, 11, 12, 13, 14, 15, 16, 17]:

Please note, this management does NOT treat the condition itself. It may mildly help with some of the symptoms, and even then has insufficient evidence to back up this claim at present. IMPORTANT: Selenium is toxic in high doses. Massive overdoses can cause kidney failure, breathing difficulty and death. Selenium should only be taken at healthy levels which the body is able to tolerate.

Recommendation: No recommendation (Available evidene does not support claims that selenium helps to prevent or treat any thyroid conditions)

Grade of Evidence: very low quality of evidence

Saw Palmetto Extract [1, 2, 3, 4, 5, 6, 7, 8]:

Please note, this management does NOT treat the condition itself. It may mildly help with some of the symptoms, and even then has insufficient evidence to back up this claim at present. Palmetto extract may cause side effects, though these are uncommon. They may include headache, vomiting, dizziness, constipation, diarrhoea, insomnia or fatigue. Long term effects have not yet been researched.

Recommendation: No recommendation (There is insufficient evidence to support claims that saw palmetto helps to treat hypothyroidism. More research is needed.)

Grade of Evidence: very low quality of evidence

Black Walnut (Juglans Nigra):

Please note, this management does NOT treat the condition itself. It is proposed only as a weak supportive symptomatic support, and even then, has insufficient evidence to back up this claim at present.

Recommendation: no recommendation (Available evidence does not support claims that Black Walnut helps to treat hypothyroidism)

Grade of Evidence: low quality of evidence

* www.gradeworkinggroup

Summary References

Treatments:

1. Ades T, Alteri R, Gansler T, Yeargin P, "Complete Guide to Complimentary & Alternative Cancer Therapies", American Cancer Society, Atlanta USA, 2009

2. http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/saw-palmetto

3. http://nccam.nih.gov/health/palmetto/

4. http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-sawpalmetto.html

5. http://www.ncbi.nlm.nih.gov/pubmed/12137626

6. http://www.ncbi.nlm.nih.gov/pubmed/16467543

7. http://www.ncbi.nlm.nih.gov/pubmed/18423748

8. http://www.mayoclinic.com/health/saw-palmetto/NS_patient-sawpalmetto

9. http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/selenium?sitearea=ETO

10. http://www.cancer.gov/Templates/doc.aspx?viewid=ED8AD8E8-6AE5-458D-8091-393F4CB73F0D

11. http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-selenium.html

12. http://www.ncbi.nlm.nih.gov/pubmed/9290116

13. http://www.ncbi.nlm.nih.gov/pubmed/9829869

14. http://www.ncbi.nlm.nih.gov/pubmed/10335455

15. http://www.ncbi.nlm.nih.gov/pubmed/2136228

16. http://www.springerlink.com/content/v0r644v4ju5153k2/

17. http://jnci.oxfordjournals.org/cgi/content/full/101/5/283

18. http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/st-johns-wort

19. http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-stjohnswort.html

20. http://www.ncbi.nlm.nih.gov/pubmed/18843608

21. http://www.ncbi.nlm.nih.gov/pubmed/11939866

22. http://nccam.nih.gov/health/stjohnswort/ataglance.htm

23. http://nccam.nih.gov/health/stjohnswort/sjw-and-depression.htm

24. http://www.nimh.nih.gov/health/publications/depression/how-is-depression-detected-and-treated.shtml

25. http://www.ncbi.nlm.nih.gov/pubmed/11939872

26. http://www.ncbi.nlm.nih.gov/pubmed/12132963

27. http://www.ncbi.nlm.nih.gov/pubmed/16423519

28. http://jama.ama-assn.org/cgi/content/full/299/22/2633

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