Familial Hypercholesterolemia
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Familial Hypercholesterolemia
This is a genetic disorder that increases the level of Low-Density Lipoprotein, which is more commonly known as “bad cholesterol” in the body. Familial Hypercholesterolemia also increases the total cholesterol level. Normally, the body usually removes excess bad cholesterol in the body via the liver but with Familial Hypercholesterolemia the liver does not function the way it should and because of this the cholesterol in the body accumulates. When this happens, the risk of cardiovascular disease increases even at a very young age. The build-up of cholesterols can also lead to muscle pains and eye problems because of the deposit of excess fats.
Efficacy of Alternative and Other Treatments According to GRADE* Ranking:
Vitamin E [1, 46, 47, 48, 49, 50, 51]:
Please note, this management does NOT treat the condition itself. It may mildly help in preventing some of the symptoms, and even then has insufficient evidence to back up this claim at present. Please note, this acts as a PREVENTATIVE treatment, and not necessarily symptomatic relief. This vitamin can have harmful effects if taken in doses higher than 100% of the recommended daily allowance.
Recommendation: No recommendation (There is insufficient evidence to support claims that vitamin E supplements can help to prevent or treat hypercholestrolemia)
Grade of Evidence: very low quality of evidence
Turmeric [1, 40, 41, 42, 43, 44, 45]:
Please note, this management does NOT treat the condition itself. It is proposed only as a weak supportive symptomatic support, and even then, has insufficient evidence to back up this claim at present.
Recommendation: Weakly in favor (Early laboratory studies show that turmeric may be of benefit in the treatment of hypercholestrolemia. However, further studies are needed)
Grade of Evidence: low quality of evidence
Selenium Supplement [1, 31, 32, 33, 34, 35, 36, 37, 38, 39]:
Please note, this management does NOT treat the condition itself. It may mildly help with some of the symptoms, and even then has insufficient evidence to back up this claim at present. IMPORTANT: Selenium is toxic in high doses. Massive overdoses can cause kidney failure, breathing difficulty and death. Selenium should only be taken at healthy levels which the body is able to tolerate.
Recommendation: No recommendation (Available evidene does not support claims that selenium helps to prevent or treat hypercholestrolemia)
Grade of Evidence: very low quality of evidence
Psyllium (Isphagula, Plantago Psyllium) [1, 25, 26, 27, 28, 29, 30]:
Please note, this management does NOT treat the condition itself. It may mildly help with some of the symptoms, and even then has insufficient evidence to back up this claim at present.
Recommendation: strongly in favor (Clinical trials have shown that Psyllium is effective in treating hypercholestrolemia)
Grade of Evidence: high quality of evidence
Pine Bark Extract [1, 22, 23, 24]:
Please note, this management does NOT treat the condition itself. It may mildly help with some of the symptoms, and even then has insufficient evidence to back up this claim at present.
Recommendation: weakly in favor (Early studies indicate potential for Pine bark extract in the treatment of hypercholestrolemia, but more clinical studies need to be done)
Grade of Evidence: low quality of evidence
Licorice (Glcyrhiz Gaba) [1, 18, 19, 20, 21]:
Please note, this management does NOT treat the condition itself. It may mildly help with some of the symptoms, and even then has insufficient evidence to back up this claim at present. Licorice has been shown to have potentially harmful side effects in people with high blood pressure, liver or kidney diseases)
Recommendation: No recommendation (There is insufficient evidence to support claims that licorice helps treat hypercholestrolemia. More research is needed)
Grade of Evidence: very low quality of evidence
Green Tea [1, 13, 14, 15, 16, 17]:
Please note, this management does NOT treat the condition itself. It may mildly help with some of the symptoms, and even then has insufficient evidence to back up this claim at present.
Recommendation: Weakly in favor (There is insufficient evidence to support claims that Green Tea helps to treat hypercholestrolemia in any way. Although reports are positive, more studies are needed.)
Grade of Evidence: low quality of evidence
Glyconutrients [1, 11, 12]:
Please note, this management does NOT treat the condition itself. It may mildly help with some of the symptoms, and even then has insufficient evidence to back up this claim at present.
Recommendation: no recommendation (Available evidence does not support claims that glyconutrients help to treat hypercholestrolemia. More studies are needed.)
Grade of Evidence: low quality of evidence
Flaxseed Oil [1, 8, 9, 10]:
Please note, this management does NOT treat the condition itself. It may mildly help with some of the symptoms, and even then has insufficient evidence to back up this claim at present.
Recommendation: no recommendation (There is insufficient evidence to support claims that flaxseed oil helps to treat hypercholesterolemia)
Grade of Evidence: low quality of evidence
Evening Primrose Oil [1, 5, 6, 7]:
Please note, this management does NOT treat the condition itself. It may mildly help with some of the symptoms, and even then has insufficient evidence to back up this claim at present.
Recommendation: no recommendation (There is insufficient evidence to support claims that Primrose Oil helps to treat hypercholestrolemia any way.)
Grade of Evidence: very low quality of evidence
Chlorella (Green Algae, Chlorella Pyrenoidosa) [1, 2, 3, 4]:
Please note, this management does NOT treat the condition itself. It may mildly help with some of the symptoms, and even then has insufficient evidence to back up this claim at present.
Recommendation: weakly in favor (Small studies have suggested possible benefits in treating hypercholestrolemia, but more research is needed)
Grade of Evidence: low quality of evidence
Red Pepper (Capsaicin):
Please note, this management does NOT treat the condition itself. It is proposed only as a weak supportive symptomatic support, and even then, has insufficient evidence to back up this claim at present.
Recommendation: no recommendation (There is insufficient evidence to support claims that red peppers help to treat or prevent hypercholestrolemia)
Grade of Evidence: very low quality of evidence
Black Walnut (Juglans Nigra):
Please note, this management does NOT treat the condition itself. It is proposed only as a weak supportive symptomatic support, and even then, has insufficient evidence to back up this claim at present.
Recommendation: weakly in favor (Available evidence supports claims that walnut helps to treat hypercholestrolemia, but more study is needed)
Grade of Evidence: low quality of evidence
* www.gradeworkinggroup.org
Summary References
Treatments:
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5. http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/evening-primrose
6. http://nccam.nih.gov/health/eveningprimrose/
7. http://news.bbc.co.uk/2/hi/health/4395826.stm
8. http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/flaxseed
9. http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-flaxseed.html
10. http://nccam.nih.gov/health/flaxseed/index.htm
11. http://abcnews.go.com/2020/story?id=3228488
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13. http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/green-tea
14. http://www.ncbi.nlm.nih.gov/pubmed/16968850
15. http://www.denverpost.com/nationworld/ci_4326770
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19. http://www.ncbi.nlm.nih.gov/pubmed/15190039
20. http://nccam.nih.gov/health/licoriceroot/
21. http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-licorice.html
22. http://www.clinicaltrials.gov/ct/show/NCT00214032
23. http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/pine-bark-extract
24. http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-pycnogenol.html
25. http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-psyllium.html
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29. http://www.mayoclinic.com/health/cholesterol-lowering-supplements/CL00013/METHOD=print
30. http://www.ageless.co.za/herb-psyllium.htm
31. http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/selenium?sitearea=ETO
32. http://www.cancer.gov/Templates/doc.aspx?viewid=ED8AD8E8-6AE5-458D-8091-393F4CB73F0D
33. http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-selenium.html
34. http://www.ncbi.nlm.nih.gov/pubmed/9290116
35. http://www.ncbi.nlm.nih.gov/pubmed/9829869
36. http://www.ncbi.nlm.nih.gov/pubmed/10335455
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41. http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-turmeric.html
42. http://nccam.nih.gov/health/turmeric/index.htm
43. http://news.bbc.co.uk/2/hi/health/1668932.stm
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45. http://clinicaltrials.gov/ct2/results?term=turmeric
46. http://nccam.nih.gov/news/alerts/vitamine/vitamine.htm
47. http://nccam.nih.gov/research/results/spotlight/070106.htm
48. http://www.nlm.nih.gov/medlineplus/vitamine.html
49. http://www.ajcn.org/cgi/content/full/76/4/703
50. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586922/?tool=pmcentrez
51. http://ods.od.nih.gov/factsheets/vitamine.asp#h3
52. http://www.nlm.nih.gov/medlineplus/ency/article/000392.htm
53. http://www.genome.gov/25520184
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55. http://community.middlebury.edu/~chem/chemistry/students/ho/fh.html
56. http://www.umm.edu/ency/article/000392sym.htm
57. http://www.medped.org/MEDPED-What-is-FH.html
58. http://www.healthcentral.com/cholesterol/introduction-3882-108.html
59. http://www.wrongdiagnosis.com/f/familial_hypercholesterolemia/intro.htm
60. http://rarediseases.info.nih.gov/GARD/Disease.aspx?diseaseID=10416
61. http://www.wrongdiagnosis.com/e/ewings_sarcoma/basics.htm
62. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC161432/?tool=pmcentrez
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