Genital Herpes Simplex
Also Know As Genital Herpes Infection
| Attributes |
Our Records are Incomplete for Condition Attributes |
Genital Herpes Simplex
Efficacy of Alternative and Other Treatments According to GRADE* Ranking:
Thuja (Eastern White Cedar, Thuja Occidentalis) [20, 41, 42, 43]:
Please note, this management does NOT treat the condition itself. It may mildly help with some of the symptoms, and even then has insufficient evidence to back up this claim at present. Little is known about the full effects of Thuja, so it is not recommended for medicinal use. Thuja can be poisonous if ingested in large amounts.
Recommendation: no recommendation (There is insufficient evidence to support claims that Thuja helps to treat herpes)
Grade of Evidence: very low quality of evidence
* www.gradeworkinggroup.org
Pokeweed Antiviral Protein (PAP) [20, 36, 37, 38, 39, 40]:
Please note, this management does NOT treat the condition itself. It may mildly help with some of the symptoms, and even then has insufficient evidence to back up this claim at present. Warning! All parts of the plant, Pokeweed (Phytolacca Americana), is poisonous and should not be ingested. Thoroughly cooking the plant reduces that toxicity. The effects of the improperly prepared plant include vomiting, diarrhoea, cramps, headache, confusion, convulstions, low blood pressure, heart block and death. Only plant extracts (PAP) or thoroughly prepared plants should be ingested, and even then, under professional medical guidance.
Recommendation: weakly in favor (Laboratory studies show that PAP may hold promise in the treatment of herpes, but more clinical trials are needed)
Grade of Evidence: very low quality of evidence
Gotu Kola (Centella Asiatica, Hydrocotyle Asiatica)[20, 30, 31, 32, 33, 34, 35]:
Please note, this management does NOT treat the condition itself. It may mildly help with some of the symptoms, and even then has insufficient evidence to back up this claim at present.
Recommendation: no recommendation (There is insufficient evidence to support claims that Gotu Kola helps in the treatment of herpes in any way. More research is needed.)
Grade of Evidence: low quality of evidence
Goldenseal (Hydrastis Canadensis) [20, 23, 24, 25, 26, 27, 28, 29]:
Please note, this management does NOT treat the condition itself. It may mildly help with some of the symptoms, and even then has insufficient evidence to back up this claim at present.
Recommendation: Weakly against (There is insufficient evidence to support claims that Goldenseal helps to treat herpes. More studies are needed. Goldenseal may produce toxic effects, including depression, constipation, rapid heartbeat, stomach pain, mouth ulcers and vomiting.)
Grade of Evidence: low quality of evidence
Celandine (Ukrain, Chelidonium Majus) [20, 21, 22]:
Please note, this management does NOT treat the condition itself. It is proposed only as a weak supportive symptomatic support, and even then, has insufficient evidence to back up this claim at present.
Recommendation: weakly against (There is insufficient evidence that Celandine helps to cure or treat herpes. In addition, the plant is mildly poisonous to humans. It may cause hepatitis as well as symptoms of pain, nausea, thirst, and fever.)
Grade of Evidence: very low quality of evidence
Cats Claw (Uncaria Tomentosa) [19, 20]:
Please note, this management does NOT treat the condition itself. It is proposed only as a weak supportive symptomatic support, and even then, has insufficient evidence to back up this claim at present.
Recommendation: no recomendation (insufficient evidence to support claims that Cats Claw can help to treat herpes)
Grade of Evidence: very low quality of evidence
Low Level Laser Therapy:
Recommendation: no recomendation (there is insufficient evidence to support claims that laser therapy helps in treating herpes)
Grade of Evidence: very low quality of evidence
Vitamin A Supplement [44, 45]:
Recommendation: no recomendation (There is insufficient evidence to support claims that vitamin A supplements are able to help treat genital herpes)
Grade of Evidence: low quality of evidence
Zinc [46, 47, 48]:
Recommendation: weakly in favor (Zinc may help prolong remissions when applied topically. More studies are needed)
Grade of Evidence: low quality of evidence
Vitamin C:
Recommendation: no recommendation (There is insufficient evidence to support claims that vitamin C is able to help treat herpes)
Grade of Evidence: very llow quality of evidence
Melissa Officinalis (Lemon Balm) [49, 50, 51]:
Recommendation: weakly in favor (Studies show that Melissa officinalis may be able to help treat herpes. More studies are needed)
Grade of Evidence: low quality of evidence
Carrageenans (Red Seaweed Extract) [52, 53, 54]:
Recommendation: weakly in favor (Studies show that red seaweed may be able to help treat herpes. More studies are needed)
Grade of Evidence: low quality of evidence
Garlic Extracts [55, 56]:
Recommendation: weakly in favor (Studies show that garlic may be able to help treat herpes. More studies are needed)
Grade of Evidence: low quality of evidence
Prunella Vulgaris (Selfheal Plant) [57, 58]:
Recommendation: weakly in favor (Studies show that prunella vulgaris may be able to help treat herpes. More studies are needed)
Grade of Evidence: low quality of evidence
Lactoferrin (Whey Protein Component) [59, 60, 61]:
Recommendation: weakly in favor (Studies show that lactoferrin may be able to help treat herpes. More studies are needed)
Grade of Evidence: low quality of evidence
Butylated Hydroxytoluene (BHT) [62]:
Recommendation: weakly in favor (Studies show that BHT may be able to help treat herpes. More studies are needed)
Grade of Evidence: low quality of evidence
Lysine Supplementation [63, 64, 65:
Recommendation: weakly in favor (Studies show that lysine may be able to help treat herpes. More studies are needed)
Grade of Evidence: low quality of evidence
Resveratol [66]:
Recommendation: No recommendation (There is insufficient evidence to support claims that reservatrol is able to help treat herpes)
Grade of Evidence: low quality of evidence
* www.gradeworkinggroup.org
Summary References
Treatments:
1. McCune MA, Perry HO, Muller SA, O'Fallon WM. (2005). "Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride". Cutis. 34 (4): 366–373. PMID 6435961
2. Griffith RS, Walsh DE, Myrmel KH, Thompson RW, Behforooz A. (1987). "Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis". Dermatologica. 175 (4): 183–190. PMID 3115841
3. Griffith RS, Norins AL, Kagan C. (1978). "A multicentered study of lysine therapy in Herpes simplex infection". Dermatologica. 156 (5): 257–267. PMID 640102
4. Vogler BK and Ernst E.. "Aloe vera: a systematic review of its clinical effectiveness.". British Journal of General Practice 49: 823–828. http://www.jr2.ox.ac.uk/bandolier/booth/alternat/AT125.html.
5. Allahverdiyev A, Duran N, Ozguven M, Koltas S. (2004). "Antiviral activity of the volatile oils of Melissa officinalis L. against Herpes simplex virus type-2.". Phytomedicine. 11 (7-8): 657–661. doi:. PMID 15636181
6. Koytchev R, Alken RG, Dundarov S (1999). "Balm mint extract (Lo-701) for topical treatment of recurring herpes labialis". Phytomedicine 6 (4): 225–30. PMID 10589440
7. Zacharopoulos VR, Phillips DM. (1997). "Vaginal formulations of carrageenan protect mice from herpes simplex virus infection". Clin. Diagn. Lab. Immunol. 4 (4): 465–468. PMID 9220165.
8. Carlucci MJ, Scolaro LA, Damonte EB. (1999). "Inhibitory action of natural carrageenans on Herpes simplex virus infection of mouse astrocytes". Chemotherapy 45 (6): 429–436. doi:. PMID 10567773.
9. Docherty JJ, Fu MM, Stiffler BS, Limperos RJ, Pokabla CM, DeLucia AL. (1999). "Resveratrol inhibition of herpes simplex virus replication". Antiviral Res. 43 (3): 145–155. doi:. PMID 10551373.
10. Docherty JJ, Smith JS, Fu MM, Stoner T, Booth T. (2004). "Effect of topically applied resveratrol on cutaneous herpes simplex virus infections in hairless mice". Antiviral Res. 61 (1): 19–26. doi:. PMID 14670590.
11. Weber ND, Andersen DO, North JA, Murray BK, Lawson LD, Hughes BG (1992). "In vitro virucidal effects of Allium sativum (garlic) extract and compounds". Planta Med. 58 (5): 417–23. doi:. PMID 1470664.
12. Chiu LC, Zhub W, Oo VE (2004). "A polysaccharide fraction from medicinal herb Prunella vulgaris downregulates the expression of herpes simplex virus antigen in Vero cells". Journal of Ethnopharmacology 93 (1): 63–68. doi:.
13. Andersen JH, Jenssen H, Gutteberg TJ. (2003). "Lactoferrin and lactoferricin inhibit Herpes simplex 1 and 2 infection and exhibit synergy when combined with acyclovir". Antiviral Res. 58 (3): 209–215. doi:. PMID 12767468.
14. Gaby AR (2006). "Natural remedies for Herpes simplex". Altern Med Rev 11 (2): 93–101. PMID 16813459.
15. Yazici AC, Baz K, Ikizoglu G (2006). "Recurrent herpes labialis during isotretinoin therapy: is there a role for photosensitivity?". J Eur Acad Dermatol Venereol 20 (1): 93–5. doi:. PMID 16405618.
16. Snipes W, Person S, Keith A, Cupp J (April 1975). "Butylated hydroxytoluene inactivated lipid-containing viruses". Science 188 (4183): 64–6. doi:. PMID 163494. http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=163494.
17. Richards JT, Katz ME, Kern ER (October 1985). "Topical butylated hydroxytoluene treatment of genital herpes simplex virus infections of guinea pigs". Antiviral Res. 5 (5): 281–90. doi:. PMID 2998276. http://linkinghub.elsevier.com/retrieve/pii/0166-3542(85)90042-7.
18. Centers for Disease Control and Prevention, Workowski KA, Berman SM. Sexually transmitted diseases treatment guidelines, 2006. MMWR Recomm Rep. 2006 Aug 4;55(RR-11):1-94.
19. http://www.nutrasanus.com/cats-claw.html
20. Ades T, Alteri R, Gansler T, Yeargin P, Complete Guide to Complimentary & Alternative Cancer Therapies, American Cancer Society, Atlanta USA, 2009
21.http://abchomeopathy.com/r.php/Chel
22.http://www.naturalstandard.com/index-abstract.asp?create-abstract=/monographs/herbssupplements/greatercelandine.asp
23. http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/goldenseal
24. http://nccam.nih.gov/health/goldenseal/
25. Tierra Michael (1998): The Way of Herbs. New York, Pocket Books
26. Grieve M. (1971): A Modern Herbal. New York, Dover Publications, Inc
27. Mills S. and Bone K. (2000): Principles and Practice of Phytotherapy. Philadelphia, Churchill Livingstone
28. Tice Raymond (1997): Goldenseal and Two of its constituent alkaloids: berberine and hydrastine Research Triangle Park, National Institute of Environmental Health Sciences, in Seiger E: Review of Toxilogical Literature
29. http://www.henriettesherbal.com/eclectic/ellingwood/hydrastis.html
30. Winston, D., Maimes, S., Adaptogens: Herbs For Strength, Stamina, and Stress Relief, 2007, pp. 226-7
31. "A Double-Blind, Placebo-Controlled Study on the Effects of Gotu Kola (Centella asiatica) on Acoustic Startle Response in Healthy Subjects". Journal of Clinical Psychopharmacology. 20(6):680-684, December 2000. Bradwejn, Jacques MD, FRCPC *; Zhou, Yueping MD, PhD ++; Koszycki, Diana PhD *; Shlik, Jakov MD, PhD
32. B. M. Hausen (1993) "Centella asiatica (Indian pennywort), an effective therapeutic but a weak sensitizer." Contact Dermatitis 29 (4), 175–179 doi:10.1111/j.1600-0536.1993.tb03532.x
33. Cataldo, A., Gasbarro, V., et al., "Effectiveness of the Combination of Alpha Tocopherol, Rutin, Melilotus, and Centella asiatica in The Treatment of Patients With Chronic Venous Insufficiency", Minerva Cardioangiology, 2001, Apr; 49(2):159-63
34. http://en.wikipedia.org/wiki/Gotu_kola#Medicinal_effects
35. http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/gotu-kola
36. http://www.cbif.gc.ca/pls/pp/ppack.info?p_psn=12&p_type=all&p_sci=sci&p_x=px
37. http://www.pfaf.org/user/Plant.aspx?LatinName=Phytolacca+americana
38. http://www.ncbi.nlm.nih.gov/pubmed/315368
39. http://www.nlm.nih.gov/medlineplus/ency/article/002874.htm
40. http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/pokeweed
41. http://www.nlm.nih.gov/medlineplus/ency/article/002769.htm
42. http://plants.usda.gov/plantguide/pdf/cs_thoc2.pdf
43. http://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v%3Aproject=medlineplus&query=thuja&x=0&y=0
44. http://www.webmd.com/genital-herpes/guide/herbs-supplements-gential-herpes
45. http://jid.oxfordjournals.org/content/189/8/1466.full
46. https://umm.edu/health/medical/altmed/condition/herpes-simplex-virus
47. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730471/
48. http://pennstatehershey.adam.com/content.aspx?productId=107&pid=33&gid=000079
49. http://www.healthassist.net/remedies/remedies-herpes.shtml
50. http://www.altmedrev.com/publications/11/2/93.pdf
51. http://www.progressivehealth.com/herpes-herbs.htm
52. http://www.ncbi.nlm.nih.gov/pubmed/15498610
53. http://www.researchgate.net/publication/8217756_Protective_effect_of_a_natural_carrageenan_on_genital_herpes_simplex_virus_infection_in_mice
54. http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.0020069
55. http://www.progressivehealth.com/herpes-herbs.htm
56. Connors MS. and Altshuler L. (2009): The Everything Guide to Herbal Remedies: An easy-to-use reference for natural health care
57. http://www.healthassist.net/remedies/remedies-herpes.shtml
58. http://www.ion.ac.uk/information/onarchives/autumnherpes-simplex-simple-solutions-troublesome-virus
59. http://www.ncbi.nlm.nih.gov/pubmed/22269645
60. https://books.google.com.au/books?id=K-sNIkLGRnEC&pg=PA36&lpg=PA36&dq
61. http://www.sciencedirect.com/science/article/pii/S0042682203007335
62. http://www.ncbi.nlm.nih.gov/pubmed/2998276
63. https://umm.edu/health/medical/altmed/condition/herpes-simplex-virus
64. https://umm.edu/health/medical/altmed/supplement/lysine
65. http://www.ion.ac.uk/information/onarchives/autumnherpes-simplex-simple-solutions-troublesome-virus
66. http://www.ncbi.nlm.nih.gov/pubmed/16125258
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