Pokeweed Antiviral Protein (PAP)

Identification
Generic Name
Pokeweed Antiviral Protein (PAP)
Brand Name

 

Indication

Condition Contra-Indication
Our Records are Incomplete for Condition-Contra Indications

 
Other Contra-Indication
Our Records are Incomplete for Other Contra-Indications

Contra-Indication
Our Records are Incomplete for Drug Contra-Indications

 
Class Contra-Indication
Our Records are Incomplete for Drug Class Contra-Indications

We have incomplete side-effect data.

Side Effects
Efficacy of Pokeweed as an Alternative Medicine According to GRADE* Ranking: 

Please note, this management does NOT treat the condition itself. It may mildly help with some of the symptoms, and even then has insufficient evidence to back up this claim at present. Warning! All parts of the plant, Pokeweed (Phytolacca Americana), is poisonous and should not be ingested. Thoroughly cooking the plant reduces that toxicity. The effects of the improperly prepared plant include vomiting, diarrhoea, cramps, headache, confusion, convulstions, low blood pressure, heart block and death. Only plant extracts (PAP) or thoroughly prepared plants should be ingested, and even then, under professional medical guidance.

Recommendation: No recommendation (There is insignificant evidence to support claims that pokeweed is able to help treat bronchitis, constipation, pneumonia, arthritis, urinary tract infections, halitosis, hemorrhoids, mastitis, mumps, peptic ulcer disease, tonsillopharyngitis, duodenal ulcer or gastric ulcer. More studies are needed)

Grade of Evidence: Very low quality of evidence



Genital Herpes Simplex [1, 2, 3, 4, 5]:

Recommendation: Weakly in favor (Laboratory studies show that PAP may hold promise in the treatment of herpes, but more clinical trials are needed)

Grade of Evidence: Very low quality of evidence


Ovarian Cancer [1, 2, 3, 4, 5]:

Recommendation: Weakly in favor (Laboratory studies show that PAP may hold promise in the treatment of ovarian cancer, but more clinical trials are needed)

Grade of Evidence: Very low quality of evidence


Breast Cancer [1, 2, 3, 4, 5]:

Recommendation: Weakly in favor (Laboratory studies show that PAP may hold promise in the treatment of breast cancer, but more clinical trials are needed)

Grade of Evidence: Very low quality of evidence


Herpes Simplex Virus Infections [1, 2, 3, 4, 5]:

Recommendation: Weakly in favor (Laboratory studies show that PAP may hold promise in the treatment of herpes, but more clinical trials are needed)

Grade of Evidence: Very low quality of evidence


Kaposis Sarcoma [1, 2, 3, 4, 5]:

Recommendation: Weakly in favor (Laboratory studies show that PAP may hold promise in the treatment of sarcomas, but more clinical trials are needed)

Grade of Evidence: Very low quality of evidence


Prostate Cancer [1, 2, 3, 4, 5]:

Recommendation: Weakly in favor (Laboratory studies show that PAP may hold promise in the treatment of prostate cancer, but more clinical trials are needed)

Grade of Evidence: Low quality of evidence


Uterine Sarcomas [1, 2, 3, 4, 5]:

Recommendation: Weakly in favor (Laboratory studies show that PAP may hold promise in the treatment of sarcomas, but more clinical trials are needed)

Grade of Evidence: Very low quality of evidence


Rhabdomyosarcoma [1, 2, 3, 4, 5]:

Recommendation: Weakly in favor (Laboratory studies show that PAP may hold promise in the treatment of sarcomas, but more clinical trials are needed)

Grade of Evidence: Very low quality of evidence


Osteosarcoma [1, 2, 3, 4, 5]:

Recommendation: Weakly in favor (Laboratory studies show that PAP may hold promise in the treatment of sarcomas, but more clinical trials are needed)

Grade of Evidence: Very low quality of evidence


Herpes Labialis [1, 2, 3, 4, 5]:

Recommendation: Weakly in favor (Laboratory studies show that PAP may hold promise in the treatment of herpes, but more clinical trials are needed)

Grade of Evidence: Very low quality of evidence


* www.gradeworkinggroup.org 

References: 
1.  Ades T, Alteri R, Gansler T, Yeargin P, "Complete Guide to Complimentary & Alternative Cancer Therapies", American Cancer Society, Atlanta USA, 2009

2. http://www.cbif.gc.ca/pls/pp/ppack.info?p_psn=12&p_type=all&p_sci=sci&p_x=px

3. http://www.pfaf.org/user/Plant.aspx?LatinName=Phytolacca+americana

4. http://www.ncbi.nlm.nih.gov/pubmed/315368

5. http://www.nlm.nih.gov/medlineplus/ency/article/002874.htm


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