Herpes Simplex Virus Infections

Also Know As Cold Sore, Herpetic Gingivostomatitis

Attributes

Commonality is common

Further Tests

Alpha-1 Antitrypsin (AAT) Concentration Alpha-1 Antintrypsin (AAT) (Increased) Cerebrospinal Fluid Albumin Concentration Albumin (Cerebrospinal Fluid, CSF) (Increased) Cerebrospinal Fluid Protein Concentration Cerebrospinal Fluid Total Protein (Increased) Cerebrospinal Fluid Protein Electrophoresis Prealbumin (Increased) Albumin (Cerebrospinal Fluid, CSF) (Increased) Cerebrospinal Fluid White Cell Differential Cerebrospinal Fluid Leukocytes (Increased) Cholinesterase (Serum Acetylcholinesterase, Pseudocholinesterase) Cholinesterase (Decreased) D-Dimer Blood Test D-Dimer (Increased) Ferritin Concentration Ferritin (Increased) Fibrin Degradation Products (FDPs, Fibrin Split Products, FSPs, Fibrin Breakdown Products, Fbps) Fibrin Split Products (Increased) Fibrin Monomers Test Fibrin Monomers (Increased) Fibrinopeptide A (FPA) Action Assay Fibrinopeptide A (FPA) (Increased) Glucagon Concentration Test Glucagon (Increased) Glucose 6 Phosphate Dehydrogenase (G6PD) Concentration Glucose 6 Phosphate Dehydrogenase (G6PD) (Decreased) haptoglobin (Hp) concentration haptoglobin (Hp) (Increased) Herpes Simplex Virus Serology Test (HSV Serology) Herpes Simplex Virus Serology (Specific Antibody for HSV) (Increased) Lymphocyte Immunophenotyping Helper T cells (CD3(plus), CD4(plus)) (Decreased) T-Suppressor (CD8) Cells (Decreased) Natural Killer Cells (CD16 Percentage) (Decreased) CD4 to CD8 Ratio (Decreased) Monocyte Absolute Count Monocytes (Increased) Neutrophil Absolute Count Segmented Neutrophils (Decreased) Plasminogen Activity Plasminogen (Increased) Platelet Count Platelets (Decreased) Potassium Concentration (K, Blood) Potassium (K, Blood) (Increased) Protein Electrophoresis (Blood, Serum Protein) Alpha-1-Globulin (Blood, Serum) (Increased) Alpha-2-Globulin (Blood, Serum) (Increased) Urine glucose concentration Urine glucose (Increased) White Blood Cell (WBC) Count White Blood Cell (WBC) (Increased)

Efficacy of Alternative and Other Treatments According to GRADE* Ranking:

Venus Flytrap Extract (Carnivora, Dionaea Muscipula) [1, 36, 37, 38]:

Please note, this management does NOT treat the condition itself. It is proposed only as a weak supportive symptomatic support, and even then, has insufficient evidence to back up this claim at present.

Recommendation: No recommendation (There is insufficient evidence to support claims that Venus flytrap extracts can help in the treatment of herpes. More research is needed.)

Grade of Evidence: very low quality of evidence

Thuja (Eastern White Cedar, Thuja Occidentalis) [1, 33, 34, 35]:

Please note, this management does NOT treat the condition itself. It may mildly help with some of the symptoms, and even then has insufficient evidence to back up this claim at present. Little is known about the full effects of Thuja, so it is not recommended for medicinal use. Thuja can be poisonous if ingested in large amounts.

Recommendation: no recommendation (There is insufficient evidence to support claims that Thuja helps to treat herpes)

Grade of Evidence: very low quality of evidence

Tea Tree Oil [1, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32]:

Please note, this management does NOT treat the condition itself. It is proposed only as a weak supportive symptomatic support, and even then, has insufficient evidence to back up this claim at present. WARNING: Tea Tree Oil is not recommended for children, pregnant women or mothers that are breastfeeding. Also, Tea tree oil should never be taken internally. Should only be used over skin, inhaled with a vaporizer, or mixed with water as a mouthwash.)

Recommendation: No recommendation (Research on the effectiveness of tea tree oil in treating herpes has yielded unreliable results.)

Grade of Evidence: low quality of evidence

Pokeweed Antiviral Protein (PAP) [1, 18, 19, 20, 21, 22]:

Please note, this management does NOT treat the condition itself. It may mildly help with some of the symptoms, and even then has insufficient evidence to back up this claim at present. Warning! All parts of the plant, Pokeweed (Phytolacca Americana), is poisonous and should not be ingested. Thoroughly cooking the plant reduces that toxicity. The effects of the improperly prepared plant include vomiting, diarrhoea, cramps, headache, confusion, convulstions, low blood pressure, heart block and death. Only plant extracts (PAP) or thoroughly prepared plants should be ingested, and even then, under professional medical guidance.

Recommendation: weakly in favor (Laboratory studies show that PAP may hold promise in the treatment of herpes, but more clinical trials are needed)

Grade of Evidence: very low quality of evidence

Gotu Kola (Centella Asiatica, Hydrocotyle Asiatica)[1, 12, 13, 14, 15, 16, 17]:

Please note, this management does NOT treat the condition itself. It may mildly help with some of the symptoms, and even then has insufficient evidence to back up this claim at present.

Recommendation: no recommendation (There is insufficient evidence to support claims that Gotu Kola helps in the treatment of herpes in any way. More research is needed.)

Grade of Evidence: low quality of evidence

Goldenseal (Hydrastis Canadensis) [1, 5, 6, 7, 8, 9, 10, 11]:

Please note, this management does NOT treat the condition itself. It may mildly help with some of the symptoms, and even then has insufficient evidence to back up this claim at present.

Recommendation: Weakly against (There is insufficient evidence to support claims that Goldenseal helps to treat herpes. More studies are needed. Goldenseal may produce toxic effects, including depression, constipation, rapid heartbeat, stomach pain, mouth ulcers and vomiting.)

Grade of Evidence: low quality of evidence

Celandine (Ukrain, Chelidonium Majus) [1, 3, 4]:

Please note, this management does NOT treat the condition itself. It is proposed only as a weak supportive symptomatic support, and even then, has insufficient evidence to back up this claim at present.

Recommendation: weakly against (There is insufficient evidence that Celandine helps to cure or treat herpes. In addition, the plant is mildly poisonous to humans. It may cause hepatitis as well as symptoms of pain, nausea, thirst, and fever.)

Grade of Evidence: very low quality of evidence

Cats Claw (Uncaria Tomentosa) [1, 2]:

Please note, this management does NOT treat the condition itself. It is proposed only as a weak supportive symptomatic support, and even then, has insufficient evidence to back up this claim at present.

Recommendation: no recomendation (insufficient evidence to support claims that Cats Claw can help to treat herpes)

Grade of Evidence: very low quality of evidence

Low level laser therapy:

Recommendation: weakly against (There have been mixed results in the very few studies performed with laser therapy in regards to herpes simplex)

Grade of Evidence: very low quality of evidence

Aromatherapy:

Recommendation: weakly against (early trials done show no support of claims that aromatherapy may help with Herpes Simplex)

Grade of Evidence: very low quality of evidence

Vitamin A Supplement [39, 40]:

Recommendation: no recomendation (There is insufficient evidence to support claims that vitamin A supplements are able to help treat genital herpes)

Grade of Evidence: low quality of evidence

Zinc [41, 42, 43]:

Recommendation: weakly in favor (Zinc may help prolong remissions when applied topically. More studies are needed)

Grade of Evidence: low quality of evidence

Vitamin C:

Recommendation: no recommendation (There is insufficient evidence to support claims that vitamin C is able to help treat herpes)

Grade of Evidence: very low quality of evidence

Melissa Officinalis (Lemon Balm) [44, 45, 46]:

Recommendation: weakly in favor (Studies show that Melissa officinalis may be able to help treat herpes. More studies are needed)

Grade of Evidence: low quality of evidence

Carrageenans (Red Seaweed Extract) [47, 48, 49]:

Recommendation: weakly in favor (Studies show that red seaweed may be able to help treat herpes. More studies are needed)

Grade of Evidence: low quality of evidence

Garlic Extracts [50, 51]:

Recommendation: weakly in favor (Studies show that garlic may be able to help treat herpes. More studies are needed)

Grade of Evidence: low quality of evidence

Prunella Vulgaris (Selfheal Plant) [52, 53]:

Recommendation: weakly in favor (Studies show that prunella vulgaris may be able to help treat herpes. More studies are needed)

Grade of Evidence: low quality of evidence

Lactoferrin (Whey Protein Component) [54, 55, 56]:

Recommendation: weakly in favor (Studies show that lactoferrin may be able to help treat herpes. More studies are needed)

Grade of Evidence: low quality of evidence

Butylated Hydroxytoluene (BHT) [57]:

Recommendation: weakly in favor (Studies show that BHT may be able to help treat herpes. More studies are needed)

Grade of Evidence: low quality of evidence

Aloe Vera:

Recommendation: no recomendation (insufficient evidence to support claims that aloe vera can help to treat herpes)

Grade of Evidence: very low quality of evidence

* www.gradeworkinggroup.org

 

Summary References

Treatments:

1. Ades T, Alteri R, Gansler T, Yeargin P, "Complete Guide to Complimentary & Alternative Cancer Therapies", American Cancer Society, Atlanta USA, 2009

2. http://www.nutrasanus.com/cats-claw.html

3. http://abchomeopathy.com/r.php/Chel

4. http://www.naturalstandard.com/index-abstract.asp?create-abstract=/monographs/herbssupplements/greatercelandine.asp

5. http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/goldenseal

6. http://nccam.nih.gov/health/goldenseal/

7. Tierra Michael (1998): The Way of Herbs. New York, Pocket Books

8. Grieve M. (1971): A Modern Herbal. New York, Dover Publications, Inc

9. Mills S. and Bone K. (2000): Principles and Practice of Phytotherapy. Philadelphia, Churchill Livingstone

10. Tice Raymond (1997): Goldenseal and Two of its constituent alkaloids: berberine and hydrastine Research Triangle Park, National Institute of Environmental Health Sciences, in Seiger E: Review of Toxilogical Literature

11. http://www.henriettesherbal.com/eclectic/ellingwood/hydrastis.html

12. Winston, D., Maimes, S., Adaptogens: Herbs For Strength, Stamina, and Stress Relief, 2007, pp. 226-7

13. "A Double-Blind, Placebo-Controlled Study on the Effects of Gotu Kola (Centella asiatica) on Acoustic Startle Response in Healthy Subjects". Journal of Clinical Psychopharmacology. 20(6):680-684, December 2000. Bradwejn, Jacques MD, FRCPC *; Zhou, Yueping MD, PhD ++; Koszycki, Diana PhD *; Shlik, Jakov MD, PhD

14.  B. M. Hausen (1993) "Centella asiatica (Indian pennywort), an effective therapeutic but a weak sensitizer." Contact Dermatitis 29 (4), 175–179 doi:10.1111/j.1600-0536.1993.tb03532.x

15. Cataldo, A., Gasbarro, V., et al., "Effectiveness of the Combination of Alpha Tocopherol, Rutin, Melilotus, and Centella asiatica in The Treatment of Patients With Chronic Venous Insufficiency", Minerva Cardioangiology, 2001, Apr; 49(2):159-63

16. http://en.wikipedia.org/wiki/Gotu_kola#Medicinal_effects

17. http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/gotu-kola

18. http://www.cbif.gc.ca/pls/pp/ppack.info?p_psn=12&p_type=all&p_sci=sci&p_x=px

19. http://www.pfaf.org/user/Plant.aspx?LatinName=Phytolacca+americana

20. http://www.ncbi.nlm.nih.gov/pubmed/315368

21. http://www.nlm.nih.gov/medlineplus/ency/article/002874.htm

22. http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/pokeweed

23. http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/tea-tree-oil

24. http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-teatreeoil.html

25. http://www.ncbi.nlm.nih.gov/pubmed/18816275

26. http://bastyrcenter.org/content/view/972/&page=

27. http://jac.oxfordjournals.org/cgi/content/full/62/4/769?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=staphaseptic&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT

28. http://www.ncbi.nlm.nih.gov/pubmed/2145499

29. http://www.ncbi.nlm.nih.gov/pubmed/9055360

30. http://www.ncbi.nlm.nih.gov/pubmed/12451368

31. http://www.ncbi.nlm.nih.gov/pubmed/9848442

32. Bishop, C.D. (1995). "Anti-viral Activity of the Essential Oil of Melaleuca alternifolia". Journal of Essential Oil Research: 641–644

33. http://www.nlm.nih.gov/medlineplus/ency/article/002769.htm

34. http://plants.usda.gov/plantguide/pdf/cs_thoc2.pdf

35. http://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v%3Aproject=medlineplus&query=thuja&x=0&y=0

36. http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/venus-flytrap

37. Parimala, R. & P. Sachdanandam 1993. Effect of plumbagin on some glucose metabolizing enzymes studied in rats in experimental hepatoma. Molecular and Cellular Biochemistry 12(1): 59–63.

38. http://jpet.aspetjournals.org/content/318/2/484

39. http://www.webmd.com/genital-herpes/guide/herbs-supplements-gential-herpes

40. http://jid.oxfordjournals.org/content/189/8/1466.full

41. https://umm.edu/health/medical/altmed/condition/herpes-simplex-virus

42. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730471/

43. http://pennstatehershey.adam.com/content.aspx?productId=107&pid=33&gid=000079

44. http://www.healthassist.net/remedies/remedies-herpes.shtml

45. http://www.altmedrev.com/publications/11/2/93.pdf

46. http://www.progressivehealth.com/herpes-herbs.htm

47. http://www.ncbi.nlm.nih.gov/pubmed/15498610

48. http://www.researchgate.net/publication/8217756_Protective_effect_of_a_natural_carrageenan_on_genital_herpes_simplex_virus_infection_in_mice

49. http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.0020069

50. http://www.progressivehealth.com/herpes-herbs.htm

51. Connors MS. and Altshuler L. (2009): The Everything Guide to Herbal Remedies: An easy-to-use reference for natural health care

52. http://www.healthassist.net/remedies/remedies-herpes.shtml

53. http://www.ion.ac.uk/information/onarchives/autumnherpes-simplex-simple-solutions-troublesome-virus

54. http://www.ncbi.nlm.nih.gov/pubmed/22269645

55. https://books.google.com.au/books?id=K-sNIkLGRnEC&pg=PA36&lpg=PA36&dq

56. http://www.sciencedirect.com/science/article/pii/S0042682203007335

57. http://www.ncbi.nlm.nih.gov/pubmed/2998276

58. https://umm.edu/health/medical/altmed/condition/herpes-simplex-virus

59. https://umm.edu/health/medical/altmed/supplement/lysine

60. http://www.ion.ac.uk/information/onarchives/autumnherpes-simplex-simple-solutions-troublesome-virus

61. http://www.ncbi.nlm.nih.gov/pubmed/16125258    

 

---