Vitamin C

Identification
Generic Name
Vitamin C
Brand Name

 

Indication

Condition Contra-Indication
Our Records are Incomplete for Condition-Contra Indications

 
Other Contra-Indication
Our Records are Incomplete for Other Contra-Indications

Contra-Indication
Our Records are Incomplete for Drug Contra-Indications

 
Class Contra-Indication
Our Records are Incomplete for Drug Class Contra-Indications

We have incomplete side-effect data.

Side Effects

Efficacy of Vitamin C According to GRADE* Ranking: 


Acute Lymphoblastic Leukemia [1]:

Recommendation: No recommendation (There is insufficient evidence to support claims that vitamin C helps to treat acute lymphoblastic leukemia)

Grade of Evidence: Very low level of evidence 


Acute Promyelocytic Leukemia [1, 2, 3, 4]:

Recommendation: Weakly in favor (Early studies show vitamin C may be able to help treat acute promyelocyctic leukemia. More studies are needed)

Grade of Evidence: Low quality of evidence 


Age Related Macular Degeneration [5]:

Recommendation: Weakly in favor (Early studies show that vitamin e may be able to slow the progression of AMD. More studies are needed)

Grade of Evidence: Low quality of evidence 


AIDS [6]:

Recommendation: No recommendation (There is insufficient evidence to show that vitamin c is able to treat AIDS)

Grade of Evidence: Very low quality of evidence 


Anaemia [7, 8, 9]:

Recommendation: No recommendation (There is insufficient evidence to support claims that vitamin c is able to treat anaemia. Although there is evidence that vitamin C enhances the absorption of iron, the efficacy in reducing anaemia/iron deficiency is not clear)

Grade of Evidence: Very low quality of evidence 


Anaemia of Chronic Disease [7, 8, 9]:

Recommendation: No recommendation (There is insufficient evidence to support claims that vitamin c is able to treat anaemia. Although there is evidence that vitamin C enhances the absorption of iron, the efficacy in reducing anaemia/iron deficiency is not clear)

Grade of Evidence: Very low quality of evidence 


Anal Cancer [10]:

Recommendation: No recommendation (There is insufficient evidence to support claims that vitamin C is able to treat anal cancer)

Grade of Evidence: Very low quality of evidence 


Anorectal Cancer [11, 12]:

Please note, this management does NOT treat the condition itself. It is proposed only as a weak supportive symptomatic support, and even then, has insufficient evidence to back up this claim at present.

Recommendation: No recommendation (There is insufficient evidence to support claims that vitamin C may be able to help treat anorectal cancer. More studies are needed)

Grade of Evidence: Very low quality of evidence 


Atherosclerosis [13, 14, 15]:

Please note, this management does NOT treat the condition itself. It may mildly help with some of the symptoms, and even then has insufficient evidence to back up this claim at present.

Recommendation: No recommendation (Current studies on whether vitamin C is helpful in treating atherosclerosis are mixed. More studies are needed)

Grade of Evidence: Low quality of evidence 


Bladder Cancer [16, 17, 18, 19, 20, 21, 22]:

Please note, this management does NOT treat the condition itself. It may mildly help in preventing some of the symptoms, and even then has insufficient evidence to back up this claim at present. Please note, this acts as a PREVENTATIVE treatment, and not necessarily symptomatic relief.

Recommendation: No recommendation (Observational and clinical trials have not shown any evidence that vitamin C has a protective or treatment effect on cancer or chronic diseases)

Grade of Evidence: Moderate quality of evidence 


Breast Cancer [23, 24, 25]:

Please note, this management does NOT treat the Breast Cancer itself. It may mildly help with some of the symptoms, and even then has insufficient evidence at present to back up this claim.

Recomendation: Weakly in favor (Studies show that vitamin C may be beneficial to those that have breast cancer. More studies are needed)

Grade of Evidence: Very low quality of evidence 


Cervical Cancer:

Please note, this management does NOT treat the condition itself. It may mildly help with some of the symptoms, and even then has insufficient evidence to back up this claim at present.

Recommendation: No recommendation (There is insufficient evidence to support claims that vitamin c may be able to help treat cervical cancer. More studies are needed)

Grade of Evidence: Very low quality of evidence 


Chronic Leukemia [1, 2, 3, 4]:

Please note, this management does NOT treat the condition itself. It is proposed only as a weak supportive symptomatic support, and even then, has insufficient evidence to back up this claim at present.

Recommendation: Weakly in favor (Early studies show vitamin C may be able to help treat chronic leukemia. More studies are needed)

Grade of Evidence: Low quality of evidence 


Chronic Myelocytic Leukemia [1, 2, 3, 4]:

Please note, this management does NOT treat the condition itself. It is proposed only as a weak supportive symptomatic support, and even then, has insufficient evidence to back up this claim at present.

Recommendation: Weakly in favor (Early studies show vitamin C may be able to help treat chronic myelocytic leukemia. More studies are needed)

Grade of Evidence: Low quality of evidence 


Cold [20, 27, 28, 29, 30, 31, 32, 33]:

Recommendation: Strongly in favor (Studies show that vitamin C may be beneficial to those that have colds)

Grade of Evidence: Moderate quality of evidence 


Colon Cancer [2, 38, 39]:

Recommendation: No recommendation (There is insufficient evidence to support claims that vitamin c may be able to help treat colon cancer. Some studies have concluded that the benefits of vitamin c in patients with colon cancer are negligible. More studies are needed)

Grade of Evidence: Very low quality of evidence 


Colorectal Cancer [2, 34, 41]:

Recommendation: No recommendation (There is insufficient evidence to support claims that vitamin c may be able to help treat colon cancer. Some studies have concluded that the benefits of vitamin c in patients with colon cancer are negligible. More studies are needed)

Grade of Evidence: Very low quality of evidence 


Community Acquired Pneumonia [35, 36]:

Recommendation: No recommendation (There is insufficient evidence to support claims that vitamin c may be able to help treat colorectal cancer. More studies are needed)

Grade of Evidence: Very low quality of evidence 


Genital Herpes Simplex:

Recommendation: No recommendation (There is insufficient evidence to support claims that vitamin C is able to help treat herpes)

Grade of Evidence: Very low quality of evidence 


Gram Negative Bacilli Pneumonia [35, 38]:

Please note, this management does NOT treat the condition itself. It is proposed only as a weak supportive symptomatic support, and even then, has insufficient evidence to back up this claim at present.

Recommendation: No recommendation (Studies on the effects of vitamin C on pneumonia have yielded mixed conclusions. More studies are needed)

Grade of Evidence: Low quality of evidence 


Herpes Simplex Virus Infections:

Recommendation: No recommendation (There is insufficient evidence to support claims that vitamin C is able to help treat herpes)

Grade of Evidence: Very low quality of evidence 


Lung Cancer [18, 19, 21, 22, 39, 40]:

Please note, this management does NOT treat the condition itself. It may mildly help in preventing some of the symptoms, and even then has insufficient evidence to back up this claim at present. Please note, this acts as a PREVENTATIVE treatment, and not necessarily symptomatic relief.

Recommendation: No recommendation (Observational and clinical trials have not shown any evidence that vitamin C has a protective or treatment effect on lung cancer)

Grade of Evidence: Moderate quality of evidence 


Prostate Cancer [18, 19, 21, 22, 39, 40]:

Please note, this management does NOT treat the condition itself. It may mildly help in preventing some of the symptoms, and even then has insufficient evidence to back up this claim at present. Please note, this acts as a PREVENTATIVE treatment, and not necessarily symptomatic relief.

Recommendation: No recommendation (Observational and clinical trials have not shown any evidence that vitamin C has a protective or treatment effect on prostate cancer)

Grade of Evidence: Moderate quality of evidence 


Alzheimer's Disease [42, 43, 44]:

RecRecommendation: No recommendation (Studies on the effect of Vitamin C on Alzheimer's Disease have found it to be preventative but not effective as a treatment of AD on its own, more research is needed.)

Grade of Evidence: Very low level of evidence


* www.gradeworkinggroup.org 



References: 
1. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798917/
2. http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0054448/
3. http://jeffreydachmd.com/vitamin-c-saves-dying-man/
4. http://www.cancer.gov/about-cancer/treatment/cam/hp/vitamin-c-pdq 
5. http://www.ncbi.nlm.nih.gov/pubmed/11594942 
6. http://www.ncbi.nlm.nih.gov/pubmed/6238227 
7. http://www.ncbi.nlm.nih.gov/pubmed/10948381 
8. http://www.nhlbi.nih.gov/health/health-topics/topics/anemia/treatment 
9. http://www.mayoclinic.org/diseases-conditions/vitamin-deficiency-anemia/basics/definition/con-20019550 
10. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388666/ 
11. http://www.ncbi.nlm.nih.gov/pubmed/11205484 
12. http://www.cancer.gov/about-cancer/treatment/cam/patient/vitamin-c-pdq 
13. http://circ.ahajournals.org/content/105/12/1396.full 
14. http://www.ncbi.nlm.nih.gov/pubmed/8821982 
15. http://news.usc.edu/7559/Large-Doses-of-Vitamin-C-Supplements-Linked-to-Atherosclerosis/ 
16. http://www.jcojournal.org/cgi/content/abstract/19/3/666 
17. http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/vitamin-c 
18. http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-vitaminc.html 
19. http://www.nlm.nih.gov/medlineplus/vitaminc.html 
20. http://www.nlm.nih.gov/medlineplus/ency/article/002145.htm 
21. http://nccam.nih.gov/research/results/spotlight/070106.htm 
22. http://www.merck.com/mmhe/sec12/ch154/ch154i.html?qt=vitamin c&alt=sh 
23. http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/hoxsey-herbal-treatment 
24. http://www.quackwatch.org/01QuackeryRelatedTopics/OTA/ota04.html 
25. http://www.ncbi.nlm.nih.gov/pubmed/15695477 
26. http://www.ncbi.nlm.nih.gov/pubmed/23440782 
27. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1795409/
28. http://www.ncbi.nlm.nih.gov/pubmed/15495002 
29. http://www.ncbi.nlm.nih.gov/pubmed/1547201 
30. http://www.ncbi.nlm.nih.gov/pubmed/9059230 
31. http://www.ncbi.nlm.nih.gov/pubmed/17636648
32. https://www.nlm.nih.gov/medlineplus/ency/article/002145.htm
33. http://www.ncbi.nlm.nih.gov/pubmed/10796569
34. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509163/
35. http://www.ncbi.nlm.nih.gov/pubmed/23925826
36. http://www.atsjournals.org/doi/full/10.1164/ajrccm.184.5.621a#.Vd2unvmqpBc
37. http://www.ncbi.nlm.nih.gov/pubmed/23925826
38. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2099400/
39. Ades T, Alteri R, Gansler T, Yeargin P, "Complete Guide to Complimentary & Alternative Cancer Therapies", American Cancer Society, Atlanta USA, 2009
40. http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/vitamin-c
41. http://www.ncbi.nlm.nih.gov/pubmed/11205484

42. http://www.jbc.org/content/286/31/27559

43. http://lpi.oregonstate.edu/mic/vitamins/vitamin-C

44. http://www.ncbi.nlm.nih.gov/pubmed/22366772


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